An inherited condition (mismatch-repair gene mutations) increasing risk of colorectal, endometrial, and other cancers.

Why Do I Need Management?

  • Up to 80% lifetime colorectal cancer risk without surveillance.
  • Elevated risk of endometrial and ovarian cancers.

How Should I Prepare?

  • Genetic counseling and testing for MSH2, MLH1, MSH6, PMS2 mutations.
  • Baseline colonoscopy at age 20–25 or 2–5 years before the youngest family case.

What Happens During Management?

  • Surveillance: Colonoscopy every 1–2 years.
  • Prophylaxis: Consider colectomy after cancer or high-grade dysplasia; hysterectomy for women after childbearing.

What Can I Expect Afterwards?

  • Continued regular surveillance for associated cancers (gastric, urinary tract).

Risks & Possible Complications

  • Surgical risks: bleeding, infection, anastomotic leak (<5%).
  • Psychosocial impact of genetic diagnosis.

Follow-Up

  • Endometrial/ovarian cancer screening in women starting at age 30–35.
  • Annual urinary tract evaluation.