{"id":2795,"date":"2026-01-17T12:56:49","date_gmt":"2026-01-17T07:56:49","guid":{"rendered":"https:\/\/doctoraklohana.com\/?p=2795"},"modified":"2026-02-24T20:24:50","modified_gmt":"2026-02-24T15:24:50","slug":"lynch-syndrome","status":"publish","type":"post","link":"https:\/\/doctoraklohana.com\/?p=2795","title":{"rendered":"Lynch Syndrome"},"content":{"rendered":"<p>An inherited condition (mismatch-repair gene mutations) increasing risk of colorectal, endometrial, and other cancers.<\/p>\n<p><strong>Why Do I Need Management?<\/strong><\/p>\n<ul>\n<li>Up to 80% lifetime colorectal cancer risk without surveillance.<\/li>\n<li>Elevated risk of endometrial and ovarian cancers.<\/li>\n<\/ul>\n<p><strong>How Should I Prepare?<\/strong><\/p>\n<ul>\n<li>Genetic counseling and testing for MSH2, MLH1, MSH6, PMS2 mutations.<\/li>\n<li>Baseline colonoscopy at age 20\u201325 or 2\u20135 years before the youngest family case.<\/li>\n<\/ul>\n<p><strong>What Happens During Management?<\/strong><\/p>\n<ul>\n<li><strong>Surveillance<\/strong>: Colonoscopy every 1\u20132 years.<\/li>\n<li><strong>Prophylaxis<\/strong>: Consider colectomy after cancer or high-grade dysplasia; hysterectomy for women after childbearing.<\/li>\n<\/ul>\n<p><strong>What Can I Expect Afterwards?<\/strong><\/p>\n<ul>\n<li>Continued regular surveillance for associated cancers (gastric, urinary tract).<\/li>\n<\/ul>\n<p><strong>Risks &amp; Possible Complications<\/strong><\/p>\n<ul>\n<li>Surgical risks: bleeding, infection, anastomotic leak (&lt;5%).<\/li>\n<li>Psychosocial impact of genetic diagnosis.<\/li>\n<\/ul>\n<p><strong>Follow-Up<\/strong><\/p>\n<ul>\n<li>Endometrial\/ovarian cancer screening in women starting at age 30\u201335.<\/li>\n<li>Annual urinary tract evaluation.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>An inherited condition (mismatch-repair gene mutations) increasing risk of colorectal, endometrial, and other cancers. Why Do I Need Management? Up to 80% lifetime colorectal cancer risk without surveillance. Elevated risk of endometrial and ovarian cancers. How Should I Prepare? Genetic counseling and testing for MSH2, MLH1, MSH6, PMS2 mutations. Baseline colonoscopy at age 20\u201325 or [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"class_list":["post-2795","post","type-post","status-publish","format-standard","hentry","category-blogs"],"_links":{"self":[{"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=\/wp\/v2\/posts\/2795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2795"}],"version-history":[{"count":1,"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=\/wp\/v2\/posts\/2795\/revisions"}],"predecessor-version":[{"id":2805,"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=\/wp\/v2\/posts\/2795\/revisions\/2805"}],"wp:attachment":[{"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctoraklohana.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}